期刊
ELECTROCHEMISTRY COMMUNICATIONS
卷 36, 期 -, 页码 92-95出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.elecom.2013.09.014
关键词
Molecularly imprinted polymer; Smart polymers; Temperature switchable electrode; Folic acid electrochemical sensor
资金
- European Commission [PIIF-GA-2009-254955]
- LIST
- Linkoping University
- Ferdowsi University of Mashhad, Iran
The combination of smart polymers with molecular imprinting offers a powerful tool to design more effective sensors and medical devices. In this study, a temperature sensitive amine-terminated poly(N-isopropylacrylamide) block with (N,N'-methylenebisacrylamide) cross-linker along with o-phenylenediamine was electropolymerised on a gold electrode in the presence of folic acid (FA) as template to produce an on/off-switchable molecularly imprinted polymer (MIP) affinity sensor for folic acid. Differential pulse voltammetry and cyclic voltammetry were used to characterise the FA-imprinted layer. Incubation of the MIP-modified electrode with FA resulted in a suppression of the ferro/ferricyanide redox process. The highest sensitivity of this temperature gated on/off-switchable folic acid sensor was achieved at 22 degrees C. Such switchable affinity materials offer considerable potential for the design of highly selective and controllable biosensors and immunoassays. (C) 2013 Elsevier B.V. All rights reserved.
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