期刊
ELECTROCHEMISTRY COMMUNICATIONS
卷 14, 期 1, 页码 13-16出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.elecom.2011.10.011
关键词
Electrochemiluminescence; Immunosensor; Alpha fetoprotein; Graphene-CdS quantum dots-alginate composites; Energy scavenging
资金
- National Natural Science Foundation of China [81072336, 20805024]
- 973 Program [2010CB635116]
- Science and Technology Department of Zhejiang Province of China [2011R405051]
- Ningbo Science and Technology Bureau [2010A610030, 2011050037]
- Ningbo University [xk111049]
- Fund for Outstanding Young Teachers in Higher Education Institutions of Zhejiang Province
An electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of alpha fetoprotein (AFP) was fabricated using graphene-CdS quantum dots-alginate (G-CdS QDs-AL) as the immobilizing support and CdSe/ZnS QDs as the label. CdSe/ZnS QDs could effectively scavenge the ECL of G-CdS QDs-AL composite, and the quenched ECL intensity depended linearly on the logarithm for AFP concentration in the range from 0.05 to 500 fg/mL. The detection limit was 20 ag/mL. The proposed ECL immunoassay protocol for AFP detection is stable, specific, highly sensitive and promising for clinical application. (C) 2011 Elsevier B.V. All rights reserved.
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