Enzymeless Glucose Detection Based on CoO/Graphene Microsphere Hybrids

An ultrasonic nebulizer-based spray method was developed to fabricate microshpere hybrids of crumpled graphene (CG) loading cobalt oxide (CoO). The as-prepared CoO/CG microsphere hybrids were used for constructing an enzymeless sensor for glucose detection in alkaline solution. The as-developed enzymeless glucose sensor exhibited rapid response (less than 3 s), high sensitivity (669.78 mu AmM-1 cm(-2)), wide detection range (0.83 mu M-8.61 mM), good reproducibility and stability, and low detection limit (0.46 mu M) (S/N=3). Moreover, the detection of glucose in human blood serum samples with the as-developed sensor agreed well with the results obtained from commercial glucose meters.