Cobalt(II) Schiff Base/Large Mesoporous Carbon Composite Film Modified Electrode as Electrochemical Biosensor for Hydrogen Peroxide and Glucose

A simple method was developed to prepare a cobalt(II) Schiff base (Co(salen))/large mesoporous carbon (LMC) composite film. The structure and electrocatalytic performance of the Co(salen)/LMC film were investigated by scanning electron microscopy (SEM) and cyclic voltammetry (CV). The Co(salen)/LMC film exhibits high electrocatalytic activity toward H2O2, such as low detection limit (8.5x10(-7)M) and wide linear concentration range (2.0x10(-6)-8.9x10(-3)M). Furthermore, glucose oxidase (GOD) was self-assembled on the surface of the Co(salen)/LMC film modified electrode. Determination of glucose in human blood serum with satisfying result was investigated by the resulting biosensor.