期刊
ELECTROANALYSIS
卷 23, 期 1, 页码 177-187出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201000440
关键词
Methotrexate; Voltammetry; Determination; Mercury meniscus modified silver solid amalgam electrode; Hanging mercury drop electrode
Voltammetric behavior of methotrexate (MTX), an important chemotherapeutic drug, has been investigated using electrochemical methods: cyclic voltammetry, direct current voltammetry and differential pulse voltammetry on a mercury meniscus modified silver solid amalgam electrode (m-AgSAE). The obtained results have been compared with those obtained using a hanging mercury drop electrode (HMDE). The optimal conditions for its determination have been found in a Britton-Robinson buffer of pH 5 with the limit of detection equal to 1.8 nM. RSD at this concentration level amounted to less than 4%. The proposed procedure of determination was verified on a real drug containing MTX.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据