期刊
ELECTROANALYSIS
卷 22, 期 23, 页码 2817-2824出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201000305
关键词
Single-walled carbon nanotubes; DNA; Methylene blue; Self-assembled monolayer; Nanostructures
资金
- Center of Advanced Nanoscale Materials, NASA [NCC3-1034, NNC08BA48A]
- NSF-EPSCoR Institute [OIA-0701525]
- Puerto Rico Industrial Development Company (PRIDCO)
- NIH-Research Initiative for Scientific Enhancement (RISE) [2 R25 GM61151]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0923021] Funding Source: National Science Foundation
An electrochemical DNA sensor was constructed using single-walled carbon nanotubes (SWNTs) attached to a self-assembled monolayer of 11-amino-1-undecanethiol on a gold surface. The voltammetric peak of methylene blue (MB), which interacts with the DNA guanine bases specifically, was used to follow the DNA hybridization process. After DNA hybridization with its complementary DNA strand, the MB electrochemical signal response decreased and the change in MB signal response was used as the basis for the electrochemical sensing of DNA hybridization. The as described DNA sensor demonstrated to have good stability, selectivity, a linear response over the DNA concentration range from 100 to 1,000 nM and a limit of detection of 7.24 nM.
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