期刊
ELECTROANALYSIS
卷 21, 期 19, 页码 2116-2124出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.200904640
关键词
Single-walled carbon nanotubes; Sensors; DNA hybridization; Guanine signal; Voltammetry; Electrochemical impedance spectroscopy; Nanotubes; Voltammetry
资金
- The Turkish Scientific and Technological Council [106S181]
- Ege University [08/ECZ/008]
- The Turkish Academy of Sciences (TUBA)
Carboxylic acid functionalized single-walled carbon nanotubes modified graphite sensors (SWCNT-PGEs) were developed for electrochemical monitoring of direct DNA hybridization related to specific sequence of Hepatitis B virus, which substantially enhance the electrochemical transduction resulting from guanine oxidation signal comparison to bare PGEs. The performance characteristics of DNA hybridization on disposable CNT-PGE were explored measuring the guanine signal in terms of optimum analytical conditions; probe and target concentration, hybridization time, and selectivity. The voltammetric results were also complemented with electrochemical impedance spectroscopy (EIS), that was used to characterize the successful construction of carbon nanotubes modification onto the surface of PGEs.
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