Simultaneous determination of acetaminophen and ascorbic acid at an unmodified boron-doped diamond electrode by differential pulse voltammetry in buffered media

A boron-doped diamond electrode (BDDE) was used for the simultaneous anodic determination Of L-ascorbic acid (AA) and acetaminophen (AC) in aqueous buffered media by differential pulse voltammetry (DPV). Linear calibration plots of anodic current peaks versus concentration were obtained for both analytes in the concentration range 0.01 - 0.1 mM with very high correlation coefficients. RSD of 2 - 3% and high sensitivities were obtained from DPV data in single and dicomponent systems. The potential applicability of the DPV technique associated with standard addition was illustrated by simultaneous determination of AA and AC in real sample solutions made up from pharmaceutical products.