期刊
JOURNAL OF PHYSICAL THERAPY SCIENCE
卷 27, 期 10, 页码 3063-3068出版社
SOC PHYSICAL THERAPY SCIENCE
DOI: 10.1589/jpts.27.3063
关键词
ER stress; GLP-1; Type 2 diabetes mellitus
资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2013S1A5A8023933]
[Purpose] The primary objective of this study was to investigate the effect of low-intensity exercise training compare with high-intensity exercise training on endoplasmic reticulum stress and glucagon-like peptide-1 in adolescents with type 2 diabetes mellitus. [Subjects and Methods] The low-intensity exercise training group performed aerobic exercise training at an intensity of <= 45% of the heart rate reserve. The high-intensity interval exercise training group performed interval exercise training at an intensity of >= 80% of the heart rate reserve. The exercise-related energy consumption was determined for both groups on a per-week basis (1,200 kcal/week). [Results] Both groups showed improvement in the glucose-regulated protein 78 and dipeptidyl peptidase-4, but the size of the between-group effect was not statistically significant. The high-intensity interval exercise training group showed a significant reduction in percentage body fat. The C-peptide level increased after the 12-weeks programs and was significantly different, between the groups. Fasting glucose, insulin resistance in the fasting state according to homeostasis model assessment, and leptin decreased after the 12-weeks exercise program and were significantly different between the groups, and glucagon-like peptide-1 increased after the 12-week exercise programs and was significantly different between the groups. [Conclusion] In conclusion high-intensity interval exercise training, as defined in this study, may lead to improvements in body composition, glycemic control, endoplasmic reticulum stress, and the glucagon-like peptide-1 in adolescents with type 2 diabetes mellitus.
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