期刊
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 6, 期 8, 页码 1340-1347出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.5b00118
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资金
- NSF [CBET-1403208, DRM-1309469]
- Ministerio de Economia e Innovacion [CTQ2012-34238]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1426193] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1403208] Funding Source: National Science Foundation
A new approach to bioelectronic Sense-and-Act systems was developed with the use of modified electrodes performing sensing and substance-releasing functions. The sensing electrode was activated by biomolecular/biological signals ranging from small biomolecules to proteins and bacterial cells. The activated sensing electrode generated reductive potential and current, which stimulated dissolution of an Fe3+-cross-linked alginate matrix on the second connected electrode resulting in the release of loaded biochemical species with different functionalities. Drug-mimicking species, antibacterial drugs, and enzymes activating a biofuel cell were released and tested for various biomedical and biotechnological applications. The studied systems offer great versatility for future applications in controlled drug release and personalized medicine. Their future applications in implantable devices with autonomous operation are proposed.
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