期刊
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 6, 期 17, 页码 3379-3383出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.5b01629
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资金
- Foundation of Strategic Research, Sweden
- Swedish Research Council [279944]
- European Research Council [279944]
- Finnish Academy [138063]
- Finnish Cultural Foundation [0131067]
- European Community [290605, 312284]
- NSF [MCB-1413360]
- European Research Council (ERC) [279944] Funding Source: European Research Council (ERC)
- Academy of Finland (AKA) [138063] Funding Source: Academy of Finland (AKA)
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1413360] Funding Source: National Science Foundation
The phytochrome family of light-switchable proteins has long been studied by biochemical, spectroscopic and crystallographic means, while a direct probe for global conformational signal propagation has been lacking. Using solution X-ray scattering, we find that the photosensory cores of several bacterial phytochromes undergo similar large-scale structural changes upon red-light excitation. The data establish that phytochromes with ordinary and inverted photocycles share a structural signaling mechanism and that a particular conserved histidine, previously proposed to be involved in signal propagation, in fact tunes photoresponse.
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