期刊
ACS NANO
卷 9, 期 4, 页码 3926-3934出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn507241v
关键词
vasculature targeting; CuS; mesoporous silica nanoparticle; theranostic nanomedicine; photothermal ablation
类别
资金
- University of Wisconsin - Madison
- National Institutes of Health [NIBIB/NCI 1R01CA169365, T32CA009206, P30CA014520]
- Department of Defense [W81XWH-11-1-0644]
- American Cancer Society [125246-RSG-13-099-01-CCE]
Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis, surface engineering, and in vivo active vasculature targeting of a new category of theranostic nanoparticle for future cancer management. Water-soluble photothermally sensitive copper sulfide nanoparticles were encapsulated in biocompatible mesoporous silica shells, followed by multistep surface engineering to form the final theranostic nanoparticles. Systematic in vitro targeting, an in vivo long-term toxicity study, photothermal ablation evaluation, in vivo vasculature targeted imaging, biodistribution and histology studies were performed to fully explore the potential of as-developed new theranostic nanoparticles.
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