期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 100, 期 -, 页码 15-26出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2013.11.025
关键词
Proteomics; Carcinus maenas; Hydrocarbons; Metals; Transplantation
资金
- Spanish Ministry of Foreign Affairs [A/016113/08]
- Spanish Ministry of Science and Education [CTM2012-38720.CO3-02]
- Ministry of Higher Education, Scientific Research and Technology, Tunisia (Unite de Recherche en Biochimie et Toxicologie Environnementale) [UR 04AGR05]
- Institution de la Recherche et de l'Enseignement Superieur Agricole, Tunisia
- Spanish Agency of International Cooperation, within the Spain-Tunisia program
This study uses proteomics approach to assess the toxic effects of contaminants in the Mediterranean crab (Carcinus maenas) after transplantation into Teboulba fishing harbour. High levels of aliphatic and aromatic hydrocarbons were detected in sediments. Although their effects on vertebrates are well described, little is known about their early biological effects in marine invertebrates under realistic conditions. Protein expression profiles of crabs caged for 15, 30 and 60 days were compared to unexposed animals. Nineteen proteins with significant expression differences were identified by capLC-mu ESI-IT MS/MS and homology search on databases. Differentially expressed proteins were assigned to five different categories of biological function including: (1) chitin catabolism, (2) proteolysis, (3) exoskeleton biosynthesis, (4) protein folding and stress response, and (5) transport. The proteins showing major expression changes in C maenas after different caging times may be considered as novel molecular biomarkers for effectively biomonitoring aquatic environment contamination. (C) 2013 Elsevier Inc. All rights reserved.
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