期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 102, 期 -, 页码 12-17出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2014.01.014
关键词
Antibiotic; Biomarker; Carassius auratus
资金
- National Natural Science Foundation of China [51279061, 51079049]
- Innovation Program of Graduate Students in Jiangsu Province [CXZZ13_0269]
In the present study, the sublethal effects of norfloxacin alone and in combination with sulfamethoxazole in goldfish (Carassius auratus) were investigated, the biomarkers including acetylcholinesterase (AChE) in brain, 7-ethoxyresorufin O-deethylase (EROD), glutathione S-transferase (GST), and superoxides dismutase (SOD) activities in liver, vitellogenin (Vtg) in serum and DNA damage in gonad were determined after 1, 2, 4 and 7 days of exposure. Brain AChE activity was significantly inhibited by norfloxacin (>= 0.4 mg/L) after 4 and 7 days and the mixtures with sulfamethoxazole (>= 0.24 mg/L) after 4 days of exposure, and significant concentration-response relationships were obtained. Liver EROD, GST and SOD activities were significantly increased by the individual and mixed pharmaceuticals in most cases and exhibited analogously bell-shaped concentration-response curves. Serum Vtg was increased by the highest concentration of norfloxacin and two higher concentrations of the mixtures. Higher concentrations of the test antibiotics induced significant DNA damage in a concentration- and time-dependent manner. The results indicated that selected antibiotics possesses cytotoxic and genotoxic potential against the non-target organism C. auratus. (C) 2014 Elsevier Inc. All rights reserved.
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