期刊
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 6, 期 11, 页码 2022-2026出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.5b00524
关键词
-
类别
资金
- [NSF-MCB-0947767]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0947767] Funding Source: National Science Foundation
Lambda Cro repressor is one of the best studied dimeric transcription factors. However, there has still been an unsettled debate for decades about whether it is a two-state dimer or three-state dimer. We provide a new mechanism model that can reconcile these seemingly conflicting (mutually exclusive) experimental results. From simulations with all-atom structure-based model, we observe that the dimerization process of Lambda Cro repressor starts from one folded monomer with one unfolded monomer. Intrasubunit folding and intersubunit binding are partially coupled, in a fly casting manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据