期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 78, 期 -, 页码 212-217出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2011.11.015
关键词
Fish; Freshwater environment; Heavy metal; Lipid peroxidation; Manganese; Oxidative stress
资金
- Ministry of Science and Innovation, government of Spain [CTM2010-14747]
- Proyecto de Excelencia [RNM-06641]
- Consejeria Innovacion, Ciencia y Empresa, Junta de Andalucia
- Plan Andaluz de Investigacion, Junta de Andalucia, Spain [BIO 282]
- University of Huelva, Spain
Manganese is a relatively common, yet poorly studied element in freshwater ecosystems, where it can be significantly bioconcentrated. The knowledge about the mechanisms of Mn toxicity on fish health is still limited. The aim of the present study was to assess the potential induction of oxidative stress and the antioxidant response after a 96 h waterborne Mn-exposure (at 0.1 and 1 mM) in gill, kidney, liver and brain of goldfish (Carassius auratus). Mn 1 mM induced an increase of lipid hydroperoxides, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in all tissues with the exception of SOD inhibition in the brain. Particular response of catalase (CAT) was indicated-its inhibition in the liver and kidney, but activation in the gill. Exposure to Mn 0.1 mM provoked most prominent changes in the liver and did not change the indexes in brain. These results strongly suggest that Mn exposure caused a generalized oxidative stress in the fish and revealed an organ specific antioxidant response involving a differential modulation of the SOD, CAT and GPx activities. (C) 2011 Elsevier Inc. All rights reserved.
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