期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 84, 期 -, 页码 9-17出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2012.05.021
关键词
Allergen; Asian dust storm; beta-hexosaminidase; RBL-2H3; Yellow sand
资金
- Japan Society for the Promotion of Science [19255017]
- Grants-in-Aid for Scientific Research [19255017] Funding Source: KAKEN
Recent studie pointed out that allergic diseases have increased during the Asian dust storm event (ADSE) in Japan. Daily observations and the atmospheric concentrations of yellow sand (YS) aerosol have been increasing. In this study, YS samples collected from three sites of Japan during ADSE in 2009-2010 were used. The particles were analyzed by X-ray photoelectron spectroscopy (XPS) and X-ray fluorescence-energy dispersive spectrometer (XRF-EDS). We investigate ability of YS extract on enhancing the chemical mediator release and cytokine production from rat basophilic leukemia (RBL-2H3) cells. The dust particles at Fukuoka and Tsukuba were abundant in aluminum (Al), iron (Fe), potassium (K) and titan (Ti) than those at Naha. Concentration of the trace endotoxin and Cryptomeria japonica pollen allergen (Cry j 1) were measured in YS extract. After exposure of RBL-2H3 cells to YS extract, the beta-hexosaminidase (beta-hex) release, tumor necrosis factor-alpha (TNF-alpha) production were enhanced in RBL-2H3 cells. This process depends on endotoxin, Cry j 1 and other allergen present in the YS extract. YS water extract also show a strong cytotoxic effect on the cells. This data suggest that low levels of endotoxin and Cry j 1 in YS may cause allergy during the ADSE. (C) 2012 Elsevier Inc. All rights reserved.
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