期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 74, 期 1, 页码 150-156出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2010.08.036
关键词
Pyrethroid insecticides; Ethyl methane sulfonate; Chromosomal aberrations; Micronucleus; Oxidative stress
资金
- University Grants Commission (UGC), Government of India
- Council of Scientific and Industrial Research (CSIR), India
Synthetic pyrethroids are considered to be safe over other insecticides. Many of the newest pyrethroids lack ecotoxicity data. However, animal data indicate that their use may pose risk to environmental biota. The cytogenetic effects of cypermethrin, an alpha-class type II pyrethroid were evaluated using robust genotoxicity assay of chromosomal aberration (CA) and micronucleus (MN) tests in highly mitotic kidney cells and in erythrocytes of a freshwater fish, Channa punctata Bloch. In order to understand biochemical mechanism of genotoxic effects, oxidative stress parameters were also studied in fish erythrocytes. Fish exposed to cypermethrin (0.4, 0.8 and 1.2 mu g/l for 48 and 72 h) showed increased frequencies of CA and MN in a concentration-dependent manner. Fish exposed to positive genotoxin, ethyl methane sulfonate (EMS) also showed significant increase in frequencies of CA and MN. The genotoxic effects were invariably accompanied and correlated with increased oxidative stress and disturbance of antioxidant enzymes. (C) 2010 Elsevier Inc. All rights reserved.
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