期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 72, 期 4, 页码 1016-1030出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2008.07.012
关键词
Long chain alcohols; Human risk assessment; Exposure assessment; MOE
资金
- International Council of Chemical Associations (ICCA)
- Soap and Detergent Association (SDA) Aliphatic Alcohols Consortium
- Global ICCA Aliphatic Alcohols Consortium
- K. Blackburn and G. Kelm
- The Procter Gamble Company
- The Environment Agency of England and Wales
- Chemicals Assessment Unit (CAU)
- The Science Group-Environment and Human Health
Representative chemicals from the long chain alcohols category have been extensively tested to define their toxicological hazard properties. These chemicals show low acute and repeat dose toxicity with high-dose effects (if any) related to minimal liver toxicity. These chemicals do not show evidence of activity in genetic toxicity tests or to the reproductive system or the developing organism. These chemicals also are not sensitizers. Irritation is dependant on chain length; generally, alcohols in the range C-6-C-11 are considered as irritant, intermediate chain lengths (C-12-C-16) alcohols are considered to be mild irritants and chain lengths of C-18 and above are considered non-irritants. These chemicals are broadly used across the consumer products industry with highest per person consumer exposures resulting from use in personal care products. Margins of exposure adequate for the protection of human health are documented for the uses of these chemicals. (C) 2008 Published by Elsevier Inc.
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