期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 72, 期 7, 页码 1849-1860出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2009.03.016
关键词
PAHs; Oxidative stress; Ruditapes decussatus; Ria Formosa lagoon; BPH; LPO; GST
资金
- Portuguese Science and Technology Foundation (FCT)
- Ministry of Science and Technology
- [PRAXIS XXI/BD/3739/94]
- Fundação para a Ciência e a Tecnologia [PRAXIS XXI/BD/3739/94] Funding Source: FCT
Clams Ruditapes decussatus were transplanted in the Ria Formosa lagoon and the variation of PAH concentrations in the whole soft tissues measured, along with a suite of biomarkers, including the following: (a) phase I and phase 11 metabolism of xenobiotics enzymes: benzo[a]pyrene hydroxylase (BPH) and glutathione S-transferase (GST); (b) antioxidant enzymes: superoxide dismutase, catalase and glutathione peroxidases and (c) lipid peroxidation (LPO) levels. Individual PAHs were differently accumulated and eliminated by R. decussatus. During the metabolisation of PAHs by R. decussatus BPH was clearly induced in the digestive gland. Moreover, ROS lead to the induction of protective antioxidant enzymes still causing oxidative damage to membranes. Therefore, BPH seems to be a relevant indicator of PAHs in R. decussatus. (C) 2009 Elsevier Inc. All rights reserved.
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