期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 72, 期 3, 页码 819-827出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2008.04.012
关键词
Quinoline; Hydroxylated quinolines; Groundwater; Contaminated sites; Ecotoxicity; Genotoxicity; Mutagenicity; Narcosis; Algae; Daphnia magna
资金
- German Ministry of Education and Research [02WN0356]
- KORA (Retention and Degradation Processes to Reduce Contaminations in Groundwater and Soil)
In the groundwater of a timber impregnation site higher concentrations of hydroxylated quinolines compared to their parent compounds quinoline and isoquinoline were found. Studying the toxicity of parent compounds and metabolites, genotoxicity was found with metabolic activation in the SOS-Chromotest and Ames fluctuation test only for quinoline. An adverse effect on algae was observed only for the parent compounds quinoline and isoquinoline, while in the Daphnia magna immobilization assay most hydroxylated quinoline derivatives showed toxicity. The highest ecotoxic potential was observed in the Vibrio fischeri luminescence-inhibition assay. Comparing experimental EC50-values with QSAR predicted ones, for all compounds apart from isoquinoline and 2(1H)-quinolinone in the V fischeri test baseline toxicity or polar nacrosis is indicated. In conclusion, the hydroxylation of quinoline leads to a detoxification of the genotoxic potential, while taken additive mixture toxicity and a safety factor into account parent compounds and metabolites are found of ecotoxicological relevance in the groundwater. (c) 2008 Elsevier Inc. All rights reserved.
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