期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 71, 期 3, 页码 880-888出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2008.01.014
关键词
Mixture toxicity; Uniform design; Organophosphorus pesticide; Concentration addition; Independent action; Q67
资金
- National Natural Science Foundation of China [20577023]
- Shanghai Basic Research Program [06JC14067]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China [200355]
Organophosphorus (OP) pesticides are ubiquitous in the surface water as mixtures. To examine the mixture toxicity in the multicomponent space, the uniform design (UD) which can explore the concentration changes with few experimental efforts was employed to design the mixtures. On the other hand, the fixed concentration ratio ray was applied into six UD mixtures and two equivalent-effect concentration Mixtures to build the whole concentration-response curves to overcome the demerit of the classical point-to-point method. The experimental toxicities of six pesticides and their mixtures to the luminescent bacterium Q67 were determined. The mixture toxicities were predicted by two models, concentration addition (CA) and independent action (IA). The results showed that all the mixture toxicities observed had no significant differences from the ones predicted by CA. However, the mixture toxicities were also well predicted by IA especially at the low-concentration section. (C) 2008 Elsevier Inc. All rights reserved.
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