期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 71, 期 2, 页码 384-389出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2007.10.014
关键词
pentachlorophenol; testosterone; ethoxyresorufin O-deethylase; glutathione S-tranferases; crucian carp
资金
- National Natural Science Foundation of China [20577022, 2002CB412307]
Pentachlorophenol (PCP), which was reported to be a typical persistent organic pollutant and environmental endocrine disruptor, may cause threat to aquatic species. In this study, serum testosterone concentration, activity of liver microsome ethoxyresorufin O-deethylase (EROD) and glutathione S-tranferases (GST) of crucian carp (Carassius carassius) exposed to PCP For 7 and 15d, respectively, were examined. The results showed that testosterone concentration was induced remarkably after 7d (P < 0.05), and the testosterone concentrations in 15 d treatment crucian carp were higher than those in 7 d treatment. It was found that there were significant effects oil activities of EROD and GST after crucian carp were exposed to PCP for 7 and 15d (P < 0.05), compared to the controls. EROD and GST activities increased with increase in PCP concentration and also with increase in time on exposure. The results indicated that serum testosterone, EROD and GST were sensitive endpoints to PCP. PCP may have endocrine disrupting activities and may affect the reproductive success of this species. It is possible that the changes of hepatic microsome enzyme activities may result in alterations of serum testosterone levels in crucian carp. (c) 2007 Elsevier Inc. All rights reserved.
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