期刊
ECOTOXICOLOGY
卷 22, 期 7, 页码 1101-1110出版社
SPRINGER
DOI: 10.1007/s10646-013-1097-2
关键词
Flame retardants; Antioxidant enzymes; Lipid peroxidation; Combined effect; Fish liver
资金
- National Natural Science Foundation of China [41071319, 20977046, 20737001]
- National Basic Research Program of China [2009CB42160-4]
- Fundamental Research Funds for the Central Universities of China [1112021101]
- Major Science and Technology Program for Water Pollution Control and Treatment of China [2012ZX07506-001]
Decabromodiphenyl ether (BDE-209) and its commercial alternative decabromodiphenyl ethane (DBDPE) are two structurally similar brominated flame retardants, with evidence of their ubiquitous existence in aquatic ecosystems. The present study was conducted to investigate the hepatic oxidative stress inducing potential of BDE-209, DBDPE, and their mixture in Carassius auratus after exposure to different doses (10, 50 and 100 mg/kg) for 7, 14 and 30 days. Results showed that oxidative stress was evoked evidently for the experimental groups with longer exposure duration, as indicated by significant inhibition in the antioxidant enzymes activities and decrease in the reduced glutathione level, as well as simultaneous elevation of lipid peroxidation level measured by malondialdehyde content. In addition, it was found that BDE-209 possessed a higher oxidative stress inducing ability than DBDPE. Considering the more pronounced antioxidant responses in combined exposure, the interaction of BDE-209 and DBDPE was presumed to be additive action.
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