期刊
ECOTOXICOLOGY
卷 22, 期 9, 页码 1384-1394出版社
SPRINGER
DOI: 10.1007/s10646-013-1124-3
关键词
Triclosan; Daphnia magna; Chronic toxicity; Antioxidant enzyme; P450 system
资金
- National Natural Science Foundation of China [U1133005]
- Program of National Science and Technology Development [2012BAC07B05]
The toxic effects of different concentrations of Triclosan (TCS) (1-128 mu g/L) on Daphnia magna (D. magna) were investigated by acute (48 h) and chronic (21-day) toxicity tests. The response of antioxidase system and Phase I metabolism process of D. magna exposed to TCS were investigated by measuring a series of biomarkers including glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), 7-ethoxyresorufin O-deethylase (EROD), Erythromycin N-demethylase (ERND) and Aminopyrine N-demethylase (APND). The 48 h LC50 of TCS was 330 mu g/L for D. magna. In the chronic test, total number of neonates per female, body length and the intrinsic rate of natural increase (r) of D. magna increased at the low exposure concentrations (1-16 mu g/L) and decreased at the high concentrations (64-128 mu g/L), while the total number of molting per adult decreased continually. The GST and CAT activities showed no significant increase in all treatments, and SOD activities were induced after 24-h exposure and inhibited after 48-h exposure at 4-128 mu g/L of concentrations. The MDA content increased after 6-h exposure but decreased after 48-h exposure at 4-128 mu g/L. EROD activities initially increased after 6-h exposure, but decreased after 24 and 48-h exposure, ERND and APND activities showed a similar temporal pattern among different treatments groups. SOD, MDA and APND were sensitive to TCS, thus they are suitable as potential biomarkers for the exposure to TCS.
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