期刊
ECOHEALTH
卷 9, 期 1, 页码 17-23出版社
SPRINGER
DOI: 10.1007/s10393-012-0751-0
关键词
transmission; simian immunodeficiency virus; primates; humans; Central Africa; bushmeat
资金
- National Institutes of Health (NIH) Fogarty International Center (FIC) AIDS International Training and Research Program [2 D 43 TW000010-16/17]
- National Institutes of Health [DP1-OD000370]
- google.org
- Skoll Foundation
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- US Armed Forces Health Surveillance Center a Division of GEIS Operations
- Department of Defense HIV/AIDS Prevention Program
- United States Agency for International Development (USAID) Emerging Pandemic Threats Program, PREDICT project [GHN-A-OO-09-00010-00]
- Government of Cameroon
- United States Embassy in Cameroon
- Agence Nationale de Recherche sur le SIDA (ANRS)
- National Institute of Health [RO1 AI 50529]
Hunting and butchering of wildlife in Central Africa are known risk factors for a variety of human diseases, including HIV/AIDS. Due to the high incidence of human exposure to body fluids of non-human primates, the significant prevalence of simian immunodeficiency virus (SIV) in non-human primates, and hunting/butchering associated cross-species transmission of other retroviruses in Central Africa, it is possible that SIV is actively transmitted to humans from primate species other than mangabeys, chimpanzees, and/or gorillas. We evaluated SIV transmission to humans by screening 2,436 individuals that hunt and butcher non-human primates, a population in which simian foamy virus and simian T-lymphotropic virus were previously detected. We identified 23 individuals with high seroreactivity to SIV. Nucleic acid sequences of SIV genes could not be detected, suggesting that SIV infection in humans could occur at a lower frequency than infections with other retroviruses, including simian foamy virus and simian T-lymphotropic virus. Additional studies on human populations at risk for non-human primate zoonosis are necessary to determine whether these results are due to viral/host characteristics or are indicative of low SIV prevalence in primate species consumed as bushmeat as compared to other retroviruses in Cameroon.
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