期刊
EARLY HUMAN DEVELOPMENT
卷 126, 期 -, 页码 23-27出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2018.08.013
关键词
Intrauterine growth restriction; Fetal programming; Cardiovascular disease; Cardiovascular dysfunction
资金
- Erasmus + Programme of the European Union [2013-0040]
- la Caixa Foundation [LCF/PR/GN14/10270005]
- Instituto de Salud Carlos III integrados en el Plan Nacional de I+D+I y cofinanciados por el ISCIII-Subdireccion General de Evaluacion y el Fondo Europeo de Desarrollo Regional (FEDER) Una manera de hacer Europa [INT16/00168, PI15/00130, PI14/00226, PI17/00675]
- Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK)
- AGAUR 2017 SGR grant [1531]
Intrauterine growth restriction is one of the most common obstetric conditions, affecting 7-10% of fetuses. Affected fetuses are actually exposed in utero to an adverse environment during the highly critical time of development and may face life-long health consequences such as increased cardiovascular risk in adulthood. Already in utero, fetuses affected by growth restriction show remodeled hearts with signs of systolic and diastolic dysfunction. Cardiovascular remodeling persist into postnatal life, from the neonatal period to adolescence, suggesting a primary fetal cardiac programming that might explain the increased cardiovascular risk later in life. In this review we summarize the current evidence on fetal cardiovascular programming in fetuses affected by growth restriction, its consequences later and possible strategies from which they could benefit to reduce their cardiovascular risk.
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