期刊
EARLY HUMAN DEVELOPMENT
卷 90, 期 10, 页码 613-619出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2014.07.010
关键词
Preterm infants; Developmental follow-up; Neonatal long term outcomes
Background: Very preterm infants (<30 weeks of gestation) are at increased risk of specific language impairment and systematic developmental follow-up is essential for the provision of targeted early intervention. Aims: To define the predictive value of early language testing and stability of language development, and perinatal and demographic risk factors for the diagnosis of SLI at 5 years, in a cohort of preterm infants. Study design: We used a retrospective hospital based cohort study. Subjects: Preterm infants <30 weeks of gestation, were cared for in NICU at RPAH, between 2004 and 2007, and prospectively enrolled in developmental follow-up. Standardised developmental assessment was done at 3 years utilising the Bayley Scales of Infant and Toddler Development-III and the Wechsler Preschool and Primary Scale of Intelligence-III was done at 5 years. Outcome measures: Predictive value and stability of early language testing were assessed with respect to SLI at 5 years, using measures of diagnostic accuracy and kappa values. Multivariate logistic regression was performed during the distribution of perinatal and demographic risk factors for SLI. Results: One-in-five met diagnostic criteria for SLI (19%, n = 24). Limited diagnostic accuracy was found with early expressive language and the stability of language scores demonstrated only fair agreement (Cohen's kappa.383). Multilingual status and extreme gestational age at 24-25 weeks were associated with a sixfold increased risk of SU (OR 6.09,95% CI 1.89-19.56; OR 6.09, 95% CI 1.28-29.0). Conclusion: We defined a high incidence of SU among our cohort, but only a limited diagnostic accuracy of early language testing. Multilingual status and extreme prematurity were independent risk factors for SLI. It remains imperative to perform continued developmental assessments beyond pre-school age to identify language impairment with greater accuracy. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.
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