期刊
EARLY HUMAN DEVELOPMENT
卷 86, 期 6, 页码 329-338出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2010.05.010
关键词
Neonatal encephalopathy; Hypoxic-ischaemic encephalopathy; Incidence; Risk factors; Epidemiology
资金
- Department of Health, England
Neonatal encephalopathy (NE) is the clinical manifestation of disordered neonatal brain function. Lack of universal agreed definitions of NE and the sub-group with hypoxic-ischaemia (HIE) makes the estimation of incidence and the identification of risk factors problematic. NE incidence is estimated as 3.0 per 1000 live births (95%Cl 2.7 to 3.3) and for HIE is 1.5 (95%Cl 1.3 to 1.7). The risk factors for NE vary between developed and developing countries with growth restriction the strongest in the former and twin pregnancy in the latter. Potentially modifiable risk factors include maternal thyroid disease, receipt of antenatal care, infection and aspects of the management of labour and delivery, although indications for some interventions were not reported and may represent a response to fetal compromise rather than the cause. It is estimated that 30% of cases of NE in developed populations and 60% in developing populations have some evidence of intrapartum hypoxic-ischaemia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据