期刊
DYES AND PIGMENTS
卷 110, 期 -, 页码 270-284出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2014.02.004
关键词
7-Hydroxycoumarins; Fluorogenic probe; Pro-fluorescence; Red-shift; Thiols; Water-solubility
资金
- Region Haute-Normandie
- CRUNCh program (CPER)
- Institut Universitaire de France (IUF)
The synthesis and photophysical properties of novel water-soluble phenol-based fluorophores derived from 3-benzothiazolyl-7-hydroxycoumarin and emitting in the range 485-631 nm are described. Further conversion into thiol-sensitive fluorogenic probes through the chemical modification of their hydroxyl group was next investigated. Depending on the type of thiol-reactive quenching moiety used (2,4-dinitrobenzenesulfonyl ester, 2,4-dinitrophenyl ether or benzoquinone-type Michael acceptors) and the water-solubilizing group(s) pre-introduced into the coumarin core, dramatic differences in the thiol-induced fluorescence activation of these pro-fluorophores under physiological conditions were observed. Results for this comparative study provide valuable informations for the selection of the most suitable structural features for designing 7-hydroxycoumarin-based long-wavelength fluorescent probes for thiol bioimaging. (C) 2014 Elsevier Ltd. All rights reserved.
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