Formation of a Polymer-Coated Inclusion Complex of D-Limonene and β-Cyclodextrin by Spray Drying

The polymer-coated inclusion complex powder formation of D-limonene and beta-cyclodextrin obtained by spray drying was investigated with respect to the effects of various types of polymer coating agents on the powder particle size and morphology. The addition of the polymer coating agent affected the average particle size, morphology, and internal structures of the spray-dried powders. The average particle diameter of the uncoated spray-dried powders was approximately 5 mu m. The powder particle size increased upon the addition of a polymer coating reagent. With the addition of 9 wt% of the polymer coating agent, an average diameter of approximately 80 mu m was obtained for the spray-dried powder particles. However, further addition showed a negligible effect on the particle size. Inclusion complex crystals were observed on the surface and inside of the powder particles.