4.6 Review

Drugs in Development for Relapsing Multiple Sclerosis

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Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

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Ocrelizumab: a step forward in the evolution of B-cell therapy

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B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis

Stephen L. Hauser et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment

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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2007)

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EXPERT OPINION ON BIOLOGICAL THERAPY (2007)

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Diminished myelin-specific T cell activation associated with increase in CTLA4 and Fas molecules in multiple sclerosis patients treated with IFN-β

Dannie E. M. Hallal-Longo et al.

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MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS

D. H. Miller et al.

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CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells

Tomoko Watanabe et al.

CLINICAL IMMUNOLOGY (2006)

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Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritis

Samy Suissa et al.

ARTHRITIS AND RHEUMATISM (2006)

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Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis

B Bielekova et al.

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A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis

CH Polman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Medicine, General & Internal

Natalizumab plus interferon beta-1a for relapsing multiple sclerosis

RA Rudick et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Medicine, General & Internal

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy

TA Yousry et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

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The window of therapeutic opportunity in multiple sclerosis

AJ Coles et al.

JOURNAL OF NEUROLOGY (2006)

Letter Clinical Neurology

Mitoxantrone treatment of multiple sclerosis: Safety considerations

RG Pratt et al.

NEUROLOGY (2005)

Review Clinical Neurology

Drug Insight: using monoclonal antibodies to treat multiple sclerosis

R Hohlfeld et al.

NATURE CLINICAL PRACTICE NEUROLOGY (2005)

Article Immunology

Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis

AL Cox et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2005)

Article Immunology

Detoxication enzyme inducers modify cytokine production in rat mixed glial cells

A Wierinckx et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Article Pharmacology & Pharmacy

Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator

H Tuvesson et al.

DRUG METABOLISM AND DISPOSITION (2005)

Article Multidisciplinary Sciences

Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β

B Bielekova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Pharmacology & Pharmacy

Pharmacokinetics of oral fumarates in healthy subjects

NHR Litjens et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)

Review Pharmacology & Pharmacy

Glatiramer acetate (Copaxone®) therapy for multiple sclerosis

S Dhib-Jalbut

PHARMACOLOGY & THERAPEUTICS (2003)

Article Dermatology

Dimethylfumarate is a potent inducer of apoptosis in human T cells

F Treumer et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)

Review Clinical Neurology

Mechanisms of action of glatiramer acetate in multiple sclerosis

O Neuhaus et al.

NEUROLOGY (2001)

Article Cell & Tissue Engineering

Pharmacokinetics of CAMPATH-1H in BMT patients

P Rebello et al.

CYTOTHERAPY (2001)

Article Medicine, General & Internal

Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis.

LD Jacobs et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)