期刊
DRUG TESTING AND ANALYSIS
卷 6, 期 7-8, 页码 805-807出版社
WILEY-BLACKWELL
DOI: 10.1002/dta.1578
关键词
methamphetamine; dietary supplements; adulteration
Pharmaceuticals and banned substances have been detected in hundreds of purportedly natural supplements. Recently, several athletes have been disqualified from competition after testing positive for the methamphetamine analog N,alpha-diethyl-phenylethylamine (N,alpha-DEPEA). Athletes have claimed they unknowingly consumed the banned stimulant in workout supplements. Three samples from different lot numbers of Craze, a workout supplement, were analyzed to detect the presence and concentration of N,alpha-DEPEA. Two labs independently identified N,alpha-DEPEA in the supplement using ultra high performance liquid chromatography (UHPLC) coupled to an LTQ Orbitrap XL mass spectrometer and UHPLC-quadruple-time-of-flight mass (Q-TOF) spectrometer, respectively. The identity of N,alpha-DEPEA was confirmed using nuclear magnetic resonance and reference standards. Manufacturer recommended servings were estimated to provide 21 to 35 mg of N,alpha-DEPEA. N,alpha-DEPEA has never been studied in humans. N,alpha-DEPEA is a methamphetamine analog; however, its stimulant, addictive and other adverse effects in humans are entirely unknown. Regulatory agencies should act expeditiously to warn consumers and remove N,alpha-DEPEA from all dietary supplements. Copyright (C) 2013 John Wiley & Sons, Ltd.
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