期刊
DRUG RESISTANCE UPDATES
卷 15, 期 1-2, 页码 39-49出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2012.01.006
关键词
Microenvironment; Context; Tumor-stroma interactions; Dormancy; Multidrug resistance
资金
- U.S. Department of Energy, Office of Biological and Environmental Research [DE-AC02-05CH1123]
- National Cancer Institute [R37CA064786, U54CA126552, R01CA057621, U54CA112970, U01CA143233, U54CA143836]
- U.S. Department of Defense [W81XWH0810736]
- Portuguese Foundation for Science and Technology [SFRH/BD/33249/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/33249/2007] Funding Source: FCT
The emergence of clinical drug resistance is still one of the most challenging factors in cancer treatment effectiveness. Until more recently, the assumption has been that random genetic lesions are sufficient to explain the progression of malignancy and escape from chemotherapy. Here we propose an additional perspective, one in which the tumor cells despite the malignant genome could find a microenvironment either within the tumor or as a dormant cell to remain polar and blend into an organized context. Targeting this dynamic interplay could be considered a new avenue to prevent therapeutic resistance, and may even provide a promising effective cancer treatment. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据