期刊
DRUG RESISTANCE UPDATES
卷 12, 期 3, 页码 74-80出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2009.03.002
关键词
Angiogenesis; VEGF; Hypoxia; HIF-1; Bevacizumab; Cancer therapeutics; Topotecan; mTOR inhibitors
资金
- National Institutes of Health [N01-CO-12400]
- National Cancer Institute
Angiogenesis, a key process for the growth of human cancers, has recently been exploited for the development of a novel class of cancer therapeutics that was thought to have wide applications and not to induce resistance in the clinical setting. Indeed, anti-angiogenic therapy has become an important option for the management of several human malignancies. However, a significant number of patients either do not respond to anti-angiogenic agents or fairly rapidly develop resistance. In addition, the benefit of anti-angiogenic therapy is relatively short-lived and the majority of patients eventually relapses and progresses. Several mechanisms of resistance to anti-angiogenic therapy have been recently proposed. The current review focuses on the role of intra-tumor hypoxia as a mechanism of resistance to anti-angiogenic agents and speculates on therapeutic approaches that might circumvent resistance and thereby improve clinical outcome. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据