期刊
DRUG NEWS & PERSPECTIVES
卷 22, 期 3, 页码 146-150出版社
PROUS SCIENCE, SA
DOI: 10.1358/dnp.2009.22.3.1354124
关键词
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Recent advances in the understanding of allergic mechanisms have highlighted the rote of immunoglobulin E (IgE) signaling in the mast cell. One of the most important kinases in the IgE signaling pathway is spleen tyrosine kinase (Syk) which has a critical function early in the signaling cascade following binding of allergen to receptor bound IgE on the mast cell. A number of Syk inhibitors have now been developed which have been shown to effectively inhibit IgE-driven mast cell degranulation and release of inflammatory cytokines in vitro and inhibit allergic responses in a variety of in vivo models. In humans, allergen-driven symptoms were reduced in allergic rhinitic patients exposed to tree pollen in an outdoor environment following intranasal dosing of the Syk inhibitor R-112. Syk therefore represents a promising target for therapeutic intervention in allergic diseases.
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