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Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine
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MOLECULAR PHARMACEUTICS (2007)
Mechanism of multidrug recognition by MDR1/ABCB1
Yasuhisa Kimura et al.
CANCER SCIENCE (2007)
Drug-metabolizing enzymes in the skin of man, rat, and pig
Franz Oesch et al.
DRUG METABOLISM REVIEWS (2007)
Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005
C. Bosetti et al.
ANNALS OF ONCOLOGY (2007)
Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers
Angelika Doerrenhaus et al.
ARCHIVES OF TOXICOLOGY (2007)
Tumour-specific expression of CYP2W1: Its potential as a drug target in cancer therapy
Maria Karlgren et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
Pregnane X Receptor: Promiscuous regulator of detoxification pathways
Marko Matic et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Xenobiotic-metabolizing enzymes in human lung
Ji Y. Zhang et al.
CURRENT DRUG METABOLISM (2006)
CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl
Miki Nakajima et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands
Liping Du et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice
Jennifer A. Loehle et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models
Ruth Heise et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)
CYP2A13 in human respiratory tissues and lung cancers: An immunohistochemical study with a new peptide-specific antibody
Liang-Ru Zhu et al.
DRUG METABOLISM AND DISPOSITION (2006)
Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450
Piyush M. Vyas et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases
Piyush M. Vyas et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions
Yoshihisa Shitara et al.
PHARMACOLOGY & THERAPEUTICS (2006)
In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N′-diacetyl metabolites
Jean-Luc Garrigue et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2006)
Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs
Mary Beth Genter et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Impact of the arylhydrocarbon receptor on eugenol- and isoeugenol-induced cell cycle arrest in human immortalized keratinocytes (HaCaT)
Michaela Kalmes et al.
BIOLOGICAL CHEMISTRY (2006)
Divergent activities of human glutathione transferases in the bioactivation of azathioprine
Birgitta I. Eklund et al.
MOLECULAR PHARMACOLOGY (2006)
Characterisation of the xenobiotic-metabolizing Cytochrome P450 expression pattern in human lung tissue by immunochemical and activity determination
Bernauer Ulrike et al.
TOXICOLOGY LETTERS (2006)
Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1
David F. Barker et al.
PHARMACOGENETICS AND GENOMICS (2006)
Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P4502W1 and limited activity of human cytochrome P4502S1
Zhong-Liu Wu et al.
MOLECULAR PHARMACOLOGY (2006)
The human intestinal cytochrome P450 pie
MF Paine et al.
DRUG METABOLISM AND DISPOSITION (2006)
Determination of three carcinogenic aromatic amines in urine of smokers and nonsmokers
K Riedel et al.
JOURNAL OF ANALYTICAL TOXICOLOGY (2006)
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1
M Karlgren et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Drug transporters in pharmacokinetics
E Petzinger et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2006)
Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue
W Meinl et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Styrene-7,8-oxide burden in ventilated, perfused lungs of mice and rats exposed to vaporous styrene
C Hofmann et al.
TOXICOLOGICAL SCIENCES (2006)
N-acetyltransferase 2 genetic polymorphism:: effects of carcinogen and haplotype on urinary bladder cancer risk
DW Hein
ONCOGENE (2006)
Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3
Ronald N. Hines
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)
Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes
Masuhiro Nishimura et al.
DRUG METABOLISM AND PHARMACOKINETICS (2006)
Expression of cytochrome P450 enzymes CYP1A1, CYP1B1, CYP2E1 and CYP4B1 in cultured transitional cells from specimens of the human urinary tract and from urinary sediments
PH Roos et al.
ARCHIVES OF TOXICOLOGY (2006)
Quantitative analysis of FMO gene mRNA levels in human tissues
J Zhang et al.
DRUG METABOLISM AND DISPOSITION (2006)
Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk
AE van Herwaarden et al.
CARCINOGENESIS (2006)
Expression of the glutathione enzyme system of human colon mucosa by localisation, gender and age
H. Hoensch et al.
CURRENT MEDICAL RESEARCH AND OPINION (2006)
Effects of the differentiated keratinocyte phenotype on expression levels of CYP1-4 family genes in human skin cells
Liping Du et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2006)
Function of human cytochrome P450s: Characterization of the orphans
FP Guengerich et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
OSTα-OSTβ:: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
N Ballatori et al.
HEPATOLOGY (2005)
Under the skin:: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes
GJ Nohynek et al.
TOXICOLOGY LETTERS (2005)
Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification
EL Stanley et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2005)
Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells
B Ebert et al.
TOXICOLOGY LETTERS (2005)
Comparative analyses of fundamental differences in membrane transport capabilities in prokaryotes and eukaryotes
QH Ren et al.
PLOS COMPUTATIONAL BIOLOGY (2005)
Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity
K Aleksa et al.
PEDIATRIC NEPHROLOGY (2005)
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors
JG Jiang et al.
CANCER RESEARCH (2005)
Cytochrorne P450 profile of colorectal cancer: Identification of markers of prognosis
M Kumarakulasingham et al.
CLINICAL CANCER RESEARCH (2005)
Localization of cytochrome P450CYP2S1 expression in human tissues by in situ hybridization and immunohistochemistry
ST Saarikoski et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2005)
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
EM Leslie et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues
D Choudhary et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Human cytochrome P4502S1: Lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine
SL Wang et al.
DRUG METABOLISM AND DISPOSITION (2005)
Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues
Y Miki et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2005)
Human kidneys play an important role in the elimination of propofol
D Takizawa et al.
ANESTHESIOLOGY (2005)
Induction of drug metabolism by forskolin: The role of the pregnane X receptor and the protein kinase A signal transduction pathway
XS Ding et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Human breast cancer resistance protein: Interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine
P Pavek et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Differential expression of cytochrome P450 isoforms in the lungs of septic animals
XX Cui et al.
CRITICAL CARE MEDICINE (2004)
Epidermal CYP2 family cytochromes P450
LP Du et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
Characterization and tissue distribution of a novel human cytochrome P450 - CYP2U1
M Karlgren et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: Hepatic enzyme-transporter interplay
YY Lau et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins - Introduction
MA Hediger et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
Regulation of UDP glucuronosyltransferases in the gastrointestinal tract
PA Gregory et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
V Lamba et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
Importance of P-glycoprotein at blood-tissue barriers
MF Fromm
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
Characterization of the rates of testosterone metabolism to various products and of glutathione transferase and sulfotransferase activities in rat intestine and comparison to the corresponding hepatic and renal drug-metabolizing enzymes
AK Sohlenius-Sternbeck et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2004)
Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide
GP Carlson
TOXICOLOGY LETTERS (2004)
Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line
TG Altuntas et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate
MN Ebert et al.
CARCINOGENESIS (2003)
Effect of retinoic acid on cell proliferation kinetics and retinoic acid receptor expression of colorectal mucosa
HB Wei et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2003)
Quantitation of cytochrome P450 mRNA levels in human skin
LG Yengi et al.
ANALYTICAL BIOCHEMISTRY (2003)
Cutaneous expression of cytochrome P450CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases
G Smith et al.
LANCET (2003)
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
W Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Expression of cytochromes P450 3A in mouse lung:: effects of dexamethasone and pregnenolone 16α-carbonitrile
M Haag et al.
ARCHIVES OF TOXICOLOGY (2003)
Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene
T Shimada et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites
R Buesen et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2003)
Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia
A Yaghi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells
M Medhora et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)
Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells
YS Zhang et al.
JOURNAL OF DERMATOLOGICAL SCIENCE (2002)
CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung:: comparison with aromatic/hydrophobic adduct formation
K Alexandrov et al.
CARCINOGENESIS (2002)
Arylamine exposures and bladder cancer risk
MC Yu et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2002)
Metabolism of N-acetylbenzidine and initiation of bladder cancer
TV Zenser et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2002)
Monitoring gene expression profile changes in bladder transitional cell carcinoma using cDNA microarray
YH Sun et al.
UROLOGIC ONCOLOGY (2002)
Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences
M Iwanari et al.
ARCHIVES OF TOXICOLOGY (2002)
mRNA expression of multiple cytochrome P450 isozymes in four types of cultured skin cells
M Saeki et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2002)
Identification of a novel dioxin-inducible cytochrome P450
SP Rivera et al.
MOLECULAR PHARMACOLOGY (2002)
Naphthalene-induced respiratory tract toxicity: Metabolic mechanisms of toxicity
A Buckpitt et al.
DRUG METABOLISM REVIEWS (2002)
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
GK Dresser et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2002)
Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544
A Gelardi et al.
TOXICOLOGY IN VITRO (2001)
High-performance liquid chromatography method for the quantification of non-radiolabelled cinnamic compounds in analytes derived from human skin absorption and metabolism experiments
CK Smith et al.
JOURNAL OF CHROMATOGRAPHY B (2001)
Changes in the expression of cytochrome P450 2E1 and the activity of carcinogen-metabolizing enzymes in Schistosoma haematobium-infected human bladder tissues
SA Sheweita et al.
TOXICOLOGY (2001)
Identification and tissue distribution of the novel human cytochrome P4502S1 (CYP2S1)
T Rylander et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects
SAJ Vaziri et al.
PHARMACOGENETICS (2001)
T cell responses to paraphenylenediamine and to its metabolites mono- and biacetyl-paraphenylenediamine
S Sieben et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2001)
Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo
SD Dertinger et al.
CARCINOGENESIS (2001)
Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
CP Strassburg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
CYP4B1 is a possible risk factor for bladder cancer in humans
S Imaoka et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol
CK Smith et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2000)
Toxicity of Trp-P-2 to cultured human and rat keratinocytes
HS Chun et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2000)
Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin
JJ Yourick et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2000)
Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1
SK Katiyar et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2000)
Localization of N-acetyltransferases NAT1 and NAT2 in human tissues
KF Windmill et al.
TOXICOLOGICAL SCIENCES (2000)
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