期刊
DRUG METABOLISM REVIEWS
卷 44, 期 4, 页码 287-301出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/03602532.2012.725414
关键词
Apoptosis; cancer; resistance; metallothioneins; zinc; NF-kappa B; protein p53; prognostic factor; tumor marker
资金
- CYTORES [GA CR P301/10/0356, CEITEC CZ.1.05/1.1.00/02.0068, IGA TP 6/2012]
Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn2+ redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in cancer diagnosis and therapy is summarized and their importance for chemoresistance is also mentioned.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据