期刊
DRUG METABOLISM REVIEWS
卷 41, 期 3, 页码 408-421出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10837450902891485
关键词
Antihistamines; cytochrome P-450; transporters; gender; genetic polymorphism; hormonal effect; variability; food
Like any other drugs, antiallergic medications can be associated with large inter- and intraindividual variability in their disposition. The best-documented examples belong to the H1 antihistamines. Variable drugs are more likely to show unpredictable therapeutic response with both increased risks of side effects and subtherapeutic dosing in individual subjects. This article will review the main factors contributing to intervariability in pharmacokinetics with a special emphasis on gender differences, genetic polymorphism, and food habits.
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