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P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice
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Regulation of mRNA expression of xenobiotic transporters by the pregnane X receptor in mouse liver, kidney, and intestine
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DRUG METABOLISM AND DISPOSITION (2006)
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RR Press et al.
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Evaluation of the utility of brain slice methods to study brain penetration
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PAMPA - A drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models
A Avdeef et al.
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Characterization of mice lacking the multidrug resistance protein Mrp2 (Abcc2)
XY Chu et al.
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Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Altered hepatobiliary disposition of 5 (and 6)-carboxy-2′,7′ -: Dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice
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DRUG METABOLISM AND DISPOSITION (2006)
Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
The role of transporters in drug interactions
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain
SG Summerfield et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone
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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)
Brain cyclosporin a levels are determined by ontogenic regulation of MDR1A expression
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DRUG METABOLISM AND DISPOSITION (2006)
Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: Relevance to in vivo prediction
A Collett et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
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Brain permeability of inhaled corticosteroids
V Arya et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2005)
Construction of a functional transporter analysis system using MDR1 knockdown Caco-2 cells
T Watanabe et al.
PHARMACEUTICAL RESEARCH (2005)
P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion
H Tahara et al.
DRUG METABOLISM AND DISPOSITION (2005)
Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice
S Resta-Lenert et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice
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JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV
DK Walker et al.
DRUG METABOLISM AND DISPOSITION (2005)
Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice
SZ Zhang et al.
DRUG METABOLISM AND DISPOSITION (2005)
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
A Doran et al.
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PHARMACEUTICAL RESEARCH (2004)
Expression, up-regulation, and transport activity of the multidrug-resistance protein ABCG2 at the mouse blood-brain barrier
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CANCER RESEARCH (2004)
Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice
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Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice
LL von Moltke et al.
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The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters
JW Polli et al.
DRUG METABOLISM AND DISPOSITION (2004)
Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice
YX Xie et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)
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J Taipalensuu et al.
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The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability
LMS Chan et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2004)
Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene
KH Banner et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo
O van Tellingen et al.
BRITISH JOURNAL OF CANCER (2003)
Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption
M Uhr et al.
BIOLOGICAL PSYCHIATRY (2003)
(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function:: in vitro and in vivo evaluation
G Luurtsema et al.
NUCLEAR MEDICINE AND BIOLOGY (2003)
Compound profiling for p-glycoprotein at the blood-brain barrier using a microplate screening system
B Bauer et al.
PHARMACEUTICAL RESEARCH (2003)
pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: Implications for drug-drug interactions
S Neuhoff et al.
PHARMACEUTICAL RESEARCH (2003)
Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines
Q Li et al.
PHARMACEUTICAL RESEARCH (2003)
Quantitative evaluation of the function of small intestinal P-glycoprotein:: Comparative studies between in situ and in vitro
Y Adachi et al.
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The role of P-glycoprotein in intestinal tumorigenesis:: disruption of mdr1a suppresses polyp formation in ApcMin/+ mice
Y Mochida et al.
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Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2
M Goto et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Prediction of human intestinal permeability using artificial membrane permeability
K Sugano et al.
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abcblab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice
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High throughput artificial membrane permeability assay for blood-brain barrier
L Di et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
HQ Dai et al.
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P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists
CP Chen et al.
DRUG METABOLISM AND DISPOSITION (2003)
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KN Faber et al.
ADVANCED DRUG DELIVERY REVIEWS (2003)
Drug efflux transporters in the CNS
HY Sun et al.
ADVANCED DRUG DELIVERY REVIEWS (2003)
ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: Implications for affective disorder
MB Muller et al.
NEUROPSYCHOPHARMACOLOGY (2003)
Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation
DO Kiesewetter et al.
NUCLEAR MEDICINE AND BIOLOGY (2003)
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AM Karssen et al.
JOURNAL OF ENDOCRINOLOGY (2002)
Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins
M Uhr et al.
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Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2002)
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CURRENT DRUG METABOLISM (2002)
mdr1a deficiency corrects sterility in Niemann-Pick C1 protein deficient female mice
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MOLECULAR REPRODUCTION AND DEVELOPMENT (2002)
Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice
RH Stephens et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Hyperosmotic mannitol activates basolateral NHE in proximal tubule from P-glycoprotein null mice
Y Miyata et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)
Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues
J Liu et al.
TOXICOLOGY (2002)
Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo
H Yamaguchi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Relevance of multidrug resistance proteins for intestinal drug absorption in vitro and in vivo
G Fricker et al.
PHARMACOLOGY & TOXICOLOGY (2002)
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein
Y Adachi et al.
PHARMACEUTICAL RESEARCH (2001)
Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease
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Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier
M Gumbleton et al.
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Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters
EM Leslie et al.
TOXICOLOGY (2001)
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DW Zhang et al.
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SJ Lee et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)
Modulation of oral bioavailability of anticancer drugs:: from mouse to man
JHM Schellens et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2000)
Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient mice
MD Eisenbraun et al.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2000)
Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
H Suzuki et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2000)
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein
C Brimer et al.
PHARMACEUTICAL RESEARCH (2000)
Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotin knockout and in wildtype mice in the hotplate test
J Lötsch et al.
LIFE SCIENCES (2000)
Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein
SJ Thompson et al.
ANESTHESIOLOGY (2000)
Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to Mdr1a P-glycoprotein gene disruption
M Uhr et al.
NEUROPSYCHOPHARMACOLOGY (2000)
Apparent lack of effect of P-glycoprotein on the gastrointestinal absorption of a substrate, tacrolimus, in normal mice
WL Chiou et al.
PHARMACEUTICAL RESEARCH (2000)
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
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JOURNAL OF CLINICAL INVESTIGATION (2000)
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