期刊
DRUG METABOLISM AND DISPOSITION
卷 38, 期 12, 页码 2091-2095出版社
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/dmd.110.035568
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资金
- National Institutes of Health National Institute of Environmental Health Sciences [ES014626]
- National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases [DK076962]
- University of Pittsburgh Department of Pharmacology and Chemical Biology
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two closely related and liver-enriched nuclear hormone receptors originally defined as xenobiotic receptors. PXR and CAR regulate the transcription of drug-metabolizing enzymes and transporters, which are essential in protecting our bodies from the accumulation of harmful chemicals. An increasing body of evidence suggests that PXR and CAR also have an endobiotic function that impacts energy homeostasis through the regulation of glucose and lipids metabolism. Of note and in contrast, disruptions of energy homeostasis, such as those observed in obesity and diabetes, also have a major impact on drug metabolism. This review will focus on recent progress in our understanding of the integral role of PXR and CAR in drug metabolism and energy homeostasis.
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