期刊
DRUG DISCOVERY TODAY
卷 19, 期 4, 页码 413-424出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.12.003
关键词
-
资金
- MRC [MR/K019074/1] Funding Source: UKRI
- British Heart Foundation [PG/09/104/28136, PG/12/63/29824] Funding Source: researchfish
- Medical Research Council [MR/K019074/1] Funding Source: researchfish
- British Heart Foundation [PG/09/104/28136, PG/12/63/29824] Funding Source: Medline
- Medical Research Council [MR/K019074/1] Funding Source: Medline
Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the K(v)7 family of voltage-gated potassium channels have been identified as being crucial mediators of this process in a variety of smooth muscle. Recently, K(v)7 channels have been shown to be involved in the pathogenesis of hypertension, as well as being implicated in other smooth muscle disorders, providing a new and inviting target for smooth muscle disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据