期刊
DRUG DISCOVERY TODAY
卷 19, 期 8, 页码 1051-1068出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2014.02.010
关键词
-
资金
- Nexus award 'Marcello Tonini'
- IBD Research Foundation
- National Institutes of Health [R01GM66189]
- Hungarian Scientific Research Fund Grants (OTKA) [CK78275, K109178]
- Hungarian Scientific Research Fund [Human MB08-1-2011-0015, OTKA84685]
Adenosine contributes to the maintenance of tissue integrity by modulating the immune system. Encouraging results have emerged with adenosine receptor ligands for the management of several inflammatory conditions in preclinical and clinical settings. However, therapeutic applications of these drugs are sometimes complicated by the occurrence of serious adverse effects. The scientific community is making intensive efforts to design novel adenosine receptor ligands endowed with greater selectivity or to develop innovative compounds acting as allosteric receptor modulators. In parallel, research is focusing on novel pharmacological entities (designated as adenosine-regulating agents) that can increase, in a site- and event-specific manner, adenosine concentrations at the inflammatory site, thereby minimizing the adverse systemic effects of adenosine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据