期刊
DRUG DISCOVERY TODAY
卷 19, 期 12, 页码 1883-1896出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2014.09.010
关键词
-
资金
- National Institutes of Health [HL082779, HL083966, HL089012, HL110125, HD031226, HL118861]
Adverse environmental conditions faced by an individual early during its life, such as gestational hypoxia, can have a profound influence on the risk of diseases, such as neurological disorders, in later life. Clinical and preclinical studies suggest that epigenetic programming of gene expression patterns in response to maternal stress have a crucial role in the fetal origins of neurological diseases. Herein, we summarize recent studies regarding the role of epigenetic mechanisms in the developmental programming of neurological diseases in offspring, primarily focusing on DNA methylation/demethylation and miRNAs. Such information could increase our understanding of the fetal origins of adult diseases and help develop effective prevention and intervention against neurological diseases.
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