期刊
DRUG DISCOVERY TODAY
卷 19, 期 1, 页码 95-102出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.07.019
关键词
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资金
- Bristol-Myers Squibb
- National Institutes of Health [R01-GM086507, R01-101135]
- research collaboration with the Waters Corporation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM101135, R01GM086507] Funding Source: NIH RePORTER
The higher order structure of protein therapeutics can be interrogated with hydrogen/deuterium exchange mass spectrometry (HDX-MS). HDX-MS is now a widely used tool in the structural characterization of protein therapeutics. In this review, HDX-MS based workflows designed for protein therapeutic discovery and development processes are presented, focusing on the specific applications of epitope mapping for protein/drug interactions and biopharmaceutical comparability studies. Future trends in the application of HDX-MS in protein therapeutics characterization are also described.
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