期刊
DRUG DISCOVERY TODAY
卷 18, 期 5-6, 页码 290-297出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.10.005
关键词
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资金
- National Natural Sciences Foundation of China [81102387]
- Natural Sciences Foundation of Shanghai China [11ZR1444700]
- National Science and Technology Major Project Key New Drug Creation and Manufacturing Program [2009ZX09301-001]
- National Basic Research Program of China [2009CB930300]
Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.
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