期刊
DRUG DISCOVERY TODAY
卷 17, 期 1-2, 页码 71-80出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2011.09.009
关键词
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资金
- Sanford Research/USD [PC073887]
- Governor's Cancer
- NIH [CA142736]
- Cancer COBRE Center [P20 RR024219]
- NATIONAL CANCER INSTITUTE [R01CA142736] Funding Source: NIH RePORTER
Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer potential. In this review, we focus on the design and development of nanoparticles, self-assemblies, nanogels, liposomes and complex fabrication for sustained and efficient curcumin delivery. We also discuss the anticancer applications and clinical benefits of nanocurcumin formulations. Only a few novel multifunctional and composite nanosystem strategies offer simultaneous therapy as well as imaging characteristics. We also summarize the challenges to developing curcumin delivery platforms and up-to-date solutions for improving curcumin bioavailability and anticancer potential for therapy.
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