期刊
DRUG DISCOVERY TODAY
卷 17, 期 5-6, 页码 269-276出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.01.019
关键词
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资金
- Cancer Research UK consortium
- Cancer Research UK [15890, 11650] Funding Source: researchfish
Senescence forms a universal block to tumorigenesis which impacts on all hallmarks of cancer, making it an attractive target for drug discovery. Therefore a strategy must be devised to focus this broad potential into a manageable drug discovery programme. Several issues remain to be addressed including the lack of robust senescence-inducing compounds and causally related biomarkers to measure cellular response. Here, we review the latest progress in translating senescence as a target for cancer therapy and some promising approaches to drug and biomarker discovery. Finally, we discuss the potential application of a senescence-induction therapy in a clinical setting.
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