期刊
DRUG DISCOVERY TODAY
卷 17, 期 15-16, 页码 913-920出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.04.008
关键词
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资金
- NSERC
- Alberta Cancer Foundation, Alberta Cancer Research Institute, Canadian Breast Cancer Foundation, Alberta Advanced Education and Technology
- Allard Foundation
Base excision repair (BER) is the fundamental pathway responsible for the elimination of damaged DNA bases and repair of DNA single-strand breaks generated spontaneously or produced by DNA-damaging agents. Among the essential enzymes that are required to achieve the BER reaction is DNA polymerase beta (pot beta), which has been regarded as a potential therapeutic target. More than 60 pol beta-inhibitors have been identified so far; however, most of them are either not potent or not specific enough to become a drug. In this article we compile an essential knowledge base regarding the structures, the modes of inhibition and the activities of these pharmacologically interesting molecules.
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