期刊
DRUG DISCOVERY TODAY
卷 17, 期 9-10, 页码 425-434出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.01.003
关键词
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资金
- Ministry of Health & Welfare, Republic of Korea [A110179]
- Korea Health Promotion Institute [A110179] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Since the introduction of drug discovery based on single targets, the number of newly developed drugs has steadily declined, and the reliablility of the current drug-discovery paradigm has been unceasingly questioned. As an alternative, an emerging approach pursuing multi-targeting drugs has arisen to reflect multifactorial diseases caused by the complex networks of various mechanisms. The purpose of this paper is to review multi-target drugs and introduce our progress in establishing a practical methodology for identifying antinociceptive multi-target drugs. We have adopted a system of ex vivo efficacy screening using long-term potentiation in rat spinal cord as a surrogate biomarker for neuropathic pain. A bait-target approach is also adopted to lure an unknown target combination that induces synergistic mechanisms.
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